EXAMINE THIS REPORT ON LSD CRYSTAL

Inside the LSD-bound crystal structure, the aspect chain in the lid residue L209EL2 kinds comprehensive hydrophobic contacts with each LSD and bordering residues in TMs III, IV, and V (Figure 4C). When the lid moved aside to show the binding pocket in simulation, a number of of these contacts broke. We thus hypothesized that L209EL2 acts being a la